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The debate surrounding artificial intelligence and its potential for consciousness has taken an unexpected turn. A recent online discussion revealed significant skepticism towards substrate independence (SI), the idea that consciousness can exist independently of the physical material it’s implemented on. The discussion was sparked by an individual attempting to explain SI to those who believe AI consciousness is impossible. They were surprised by the strength and variety of arguments against it. These arguments include concerns about the necessity of energy and embodiment for consciousness, anti-reductionist philosophies, the importance of biological evolution’s continuous process, and the absence of concrete empirical support for SI. While not completely dismissing SI, the discussion highlights the ongoing controversy. The originator of the discussion seeks to understand the scientific basis for opposing SI, having previously perceived the opposition as stemming from an overly reverent view of biochemistry. The exchange suggests a need for a deeper examination of the challenges to SI and its implications for the future of AI.