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A new AI-driven approach is dramatically accelerating the mapping of complex DNA structures, potentially transforming our understanding of and fight against diseases such as cancer and neurodegenerative disorders. Developed by researchers at the University of Sheffield, the system uses artificial intelligence to analyze tangled DNA knots with nanometer-level precision, reducing analysis time from hours to mere seconds. This breakthrough allows scientists to investigate the critical link between DNA shape and cellular function, opening up new avenues for drug discovery and targeted therapies. The development promises to provide key insights into how DNA organization impacts disease development and progression.